Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation

A convenient approach to [1,2,5]­oxadiazolo­[3′,4′:5,6]­pyrazino­[2,3-b]­indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald–Hartwig and subsequent annulation by intramolecular oxidative cyclodehydrogenation. The photophysical properties for new polycycles have been measured.

开发了一种便捷的合成策略，用于制备主链带有各类芳基取代基的[1,2,5]噁二唑并[3′,4′:5,6]吡嗪并[2,3-b]吲哚及其杂环稠合类似物。该合成方案以Pd催化的布赫瓦尔德-哈特维格（Buchwald–Hartwig）反应为基础，后续通过分子内氧化环脱氢反应完成稠环化。已对这类新型多环化合物的光物理性质进行了测试表征。