pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-thioxopropan-2-yl)acetamide (ligand 4)

pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamothioyl) pyrrolidin-1-yl)-1-thioxopropan-2-yl)acetamide (ligand 4) Descriptor: Elongin-B, Elongin-C, von Hippel-Lindau disease tumor suppressor, ... Authors: Soares, P, Lucas, X, Ciulli, A. Deposit date: 2018-01-31 Release date: 2018-04-11 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Thioamide substitution to probe the hydroxyproline recognition of VHL ligands. Bioorg. Med. Chem., 26, 2018

本数据集所表征的复合物为pVHL、延伸因子B（Elongin-B）、延伸因子C（Elongin-C）与配体4：N-((S)-1-((2S,4R)-4-羟基-2-((4-(4-甲基噻唑-5-基)苄基)氨基硫甲酰基)吡咯烷-1-基)-1-硫代丙基-2-基)乙酰胺的结合体。描述符：延伸因子B（Elongin-B）、延伸因子C（Elongin-C）、希佩尔-林道病肿瘤抑制蛋白（von Hippel-Lindau disease tumor suppressor）等。作者：Soares P、Lucas X、Ciulli A。存储日期：2018-01-31。发布日期：2018-04-11。最后修改日期：2024-11-06。实验方法：X射线衍射（分辨率2.75 Å）。引用文献：《硫代酰胺取代用于探究VHL配体的羟脯氨酸识别》，《Bioorganic & Medicinal Chemistry》，26卷，2018年。