Additional file 2 of Genomic and immune profiling of breast cancer brain metastases

Supplementary Material 2. Pathways of interest tested. 79 pathways of interest from Hallmark pathways, KEGG, Gene Ontology (GO), and literature were selected a priori and included pathways relevant to oxidative phosphorylation, MAPK interacting serine/threonine Kinase (MNK), cyclin dependent kinase (CDK), DNA damage repair, and immune signaling. Column names include: Pathway type, biologically-relevant pathway group name; Pathway name, unique pathway identifier; Number of genes, number of genes in pathway; Source, source of pathway.

补充材料2. 待检测的目标通路。研究人员预先从Hallmark特征通路集（Hallmark pathways）、京都基因与基因组百科全书（KEGG）、基因本体（Gene Ontology，GO）及已发表文献中筛选出79个目标通路，这些通路均与氧化磷酸化、丝裂原活化蛋白激酶互作丝氨酸/苏氨酸激酶（MAPK interacting serine/threonine Kinase，MNK）、细胞周期蛋白依赖性激酶（cyclin dependent kinase，CDK）、DNA损伤修复以及免疫信号通路相关。列字段说明如下：Pathway type（通路类型）：具有生物学相关性的通路组别名称；Pathway name（通路名称）：唯一的通路标识符；Number of genes（基因数量）：该通路内所含的基因数目；Source（来源）：通路的获取来源。