Single-Cell Gene Expression Profiling reveals distinct exhaustion and senescence signatures in T cells across various types of male infertility

scRNA-seq experiment of fertile, Oligo-Astheno-Terato spermia and idiopathic non-obstructive azoospermia subjects. scRNA-seq was applied to CD3+ T cells negatively isolated from peripheral blood of fertile (FER, n=5), Oligo-Astheno-Terato spermia (OAT, n=4), and idiopathic non-obstructive azoospermia (NOA, n=6) subjects.

本数据集包含针对生育能力正常者、少弱畸精子症患者与特发性非梗阻性无精子症受试者开展的单细胞RNA测序（single-cell RNA sequencing，scRNA-seq）实验。实验采用scRNA-seq技术，对从生育能力正常（FER，n=5）、少弱畸精子症（OAT，n=4）及特发性非梗阻性无精子症（NOA，n=6）受试者的外周血中经阴性分选分离得到的CD3阳性T细胞进行测序分析。