Hepatic transcriptome of wildtype and Cugbp1 knockout mouse neonates.

We characterize the hepatic transcriptome of wildtype and Cugpb1 knockout mice at day 3 of life using the Agilent Whole Mouse Genome Oligo Microarray, focusing on the role of Cugbp1 in the differentiation of hepatic stem cells into hepatocytes. Transcriptomic profiles were obtained for wildtype and Cugbp1 mice in triplicate using the Agilent Whole Mouse Genome Oligo Microarray.

本研究采用安捷伦全小鼠基因组寡核苷酸微阵列（Agilent Whole Mouse Genome Oligo Microarray），对出生后第3天的野生型及Cugpb1基因敲除小鼠的肝脏转录组进行表征，重点探究Cugbp1在肝干细胞向肝细胞分化过程中的作用。针对野生型与Cugpb1基因敲除小鼠，本研究均设置三次生物学重复，通过该微阵列平台获取其转录组谱。