PREDICTION OF TOXICITY OF THE USUAL STABILIZERS IN NITROCELLULOSE BASED PROPELLANTS AND THEIR MAIN DEGRADATION PRODUCTS

This work aims to establish a hierarchy of risks of the stabilizers used in nitrocellulose-based propellants concerning to toxicity, carcinogenicity and mutagenicity. Four stabilizers - diphenylamine, ethyl centralite, akardite-II and 2-nitrodiphenylamine - and their products of degradation were investigated. The prediction of the toxicity was based on the analysis of their structures with the software Lazar, using the OpenTox framework. Our results provide a quantitative reference of the risks involved in the manufacturing and disposal of propellants due to the use of such stabilizers.

本研究旨在针对硝化纤维基推进剂中所用的稳定剂，建立其在毒性、致癌性与致突变性维度下的风险层级体系。本次研究选取四种稳定剂——二苯胺（diphenylamine）、乙基中定剂（ethyl centralite）、阿卡德II（akardite-II）以及2-硝基二苯胺（2-nitrodiphenylamine）——及其降解产物作为研究对象展开分析。毒性预测环节依托OpenTox框架，借助Lazar软件对各受试物质的分子结构进行解析得以实现。本研究结果可为该类稳定剂应用于推进剂制造与处置环节所伴随的相关风险提供量化参考依据。