Ectopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice

Transcriptome analysis revealed the most significantly affected pathways in the Cxcr4 deficient developing cerebellum are involved in extra cellular matrix receptor interactions and focal adhesion We isolated the cerebellum WT (n=8) and CXCR4 KO(n=7) P1 mice, and run illumina mice gene expression array to compare the gene expression pattern between this two groups.

转录组分析（Transcriptome analysis）结果表明，在Cxcr4缺陷型发育中小脑中，受影响最为显著的通路涉及细胞外基质受体相互作用与黏着斑（focal adhesion）。我们分离了野生型（Wild Type, WT，n=8）与CXCR4基因敲除型（Knock Out, KO，n=7）的出生后1天（Postnatal day 1, P1）小鼠小脑，并通过因美纳（Illumina）小鼠基因表达芯片开展检测，以比较两组的基因表达模式。