IDENTIFICATION AND FUNCTIONAL DEMONSTRATION OF A FETAL-SPECIFIC AXIS THAT POTENTLY SUPPRESSES MLL-FUSION DRIVEN MURINE AML RNA-seq [L28BME vs ME]. IDENTIFICATION AND FUNCTIONAL DEMONSTRATION OF A FETAL-SPECIFIC AXIS THAT POTENTLY SUPPRESSES MLL-FUSION DRIVEN MURINE AML RNA-seq [L28BME vs ME]

LIN28B suppresses MLL-ENL driven AML. The tumor suppressor effects of LIN28B are largely driven by positive regulation of MYBBP1A. Overall design: RNA-seq was performed on GMLPs (Lin- Kit+ SCa1+ CD48+ CD150-) from ME or L28BME mice (3 replicates per group).

LIN28B可抑制MLL-ENL驱动的急性髓系白血病（Acute Myeloid Leukemia, AML）。LIN28B的抑瘤作用主要通过正向调控MYBBP1A实现。实验设计概况：对取自ME小鼠与L28BME小鼠的粒细胞巨噬细胞祖细胞（Granulocyte-Macrophage Progenitors, GMLPs）（Lin⁻ Kit⁺ SCa1⁺ CD48⁺ CD150⁻）开展RNA测序（RNA Sequencing, RNA-seq），每组设置3个生物学重复。