Replication data for: Characterization of naturally acquired immunity to a panel of antigens expressed in mature P. falciparum gametocytes

We used data from a longitudinally monitored cohort of children and adults from Kilifi county located along the Kenyan coast collected between 1998-2016 to describe the factors associated with the acquisition of antibody responses to antigens expressed on the surface of mature gametocytes. A panel of candidate gametocyte antigens were identified and produced as recombinant protein for this analysis. The datasets comprise data from cross-sectional surveys carried out to assess parasite prevalence. The datasets were used to carry out analyses aimed at describing the seroprevalence of antibodies to the candidate antigens, and assess the factors associated with antibody responses to these antigens. The overall aim of the analyses was to improve our understanding of immunity to the transmissible stages of the malaria parasite.

本研究使用1998年至2016年间采集自肯尼亚沿海基利菲县的纵向监测队列数据，研究对象涵盖儿童与成人，旨在阐明与成熟配子体（mature gametocytes）表面抗原的抗体应答获得相关的影响因素。本次分析中，研究团队已鉴定出一组候选配子体抗原，并将其制备为重组蛋白（recombinant protein）以供使用。本数据集包含用于评估寄生虫感染率的横断面调查数据，被用于开展两类分析：一是描述候选抗原的抗体血清阳性率（seroprevalence），二是评估与这些抗原的抗体应答相关的影响因素。本次系列分析的核心目标是加深我们对疟原虫（malaria parasite）传播阶段免疫机制的认知。