Magnetoelncephalography (MEG) recordings from a phantom with Deep Brain Stimulation (DBS) artefacts

This dataset was acquired in an experiment aimed at testing the effects of Deep Brain Stimulation (DBS) artefacts on MEG recordings using MEG phantom. The experimental procedures are described and the results are reported in the following publication:<br>Oswal A, Jha A, Neal S, Reid A, Bradbury D, Aston P, Limousin P, Foltynie T, Zrinzo L, Brown P, Litvak V. Analysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation. J Neurosci Methods. 2016 Mar 1;261:29-46. doi: 10.1016/j.jneumeth.2015.11.029. Epub 2015 Dec 14.<br>We tested different combinations of presence of ferromagnetic connection wires, movements designed to emulate breathing and heart-beat related artefacts in real patients (see paper for details) and DBS which could be bipolar (only inducing weak artefacts) and monopolar (inducing severe artefacts).<br>We tested 3 stimulation frequencies: 5Hz, 20Hz and 130Hz<br>The datasets included here are as follows:<br>phantom090715_BrainampDBS_20150709_01.ds.zip -wires+ , movement-, stimulation-phantom090715_BrainampDBS_20150709_02.ds.zip - wires- , movement-, stimulation- %This is a clean dataset that can be used as a referencephantom090715_BrainampDBS_20150709_03.ds.zip - wires- , movement-, stimulation+130Hz monopolarphantom090715_BrainampDBS_20150709_04.ds.zip - wires- , movement+, stimulation+130Hz monopolarphantom090715_BrainampDBS_20150709_05.ds.zip - wires- , movement-, stimulation+130Hz monopolarphantom090715_BrainampDBS_20150709_06.ds.zip - wires+ , movement-, stimulation+130Hz monopolarphantom090715_BrainampDBS_20150709_07.ds.zip - wires+ , movement+, stimulation+130Hz monopolar %This is the most realistic dataset for clinical frequency DBSphantom090715_BrainampDBS_20150709_08.ds.zip - wires+ , movement+, stimulation-phantom090715_BrainampDBS_20150709_09.ds.zip - wires+ , movement-, stimulation+20Hz monopolarphantom090715_BrainampDBS_20150709_10.ds.zip - wires+ , movement-, stimulation+5Hz monopolarphantom090715_BrainampDBS_20150709_11.ds.zip - wires+ , movement+, stimulation+5Hz monopolarphantom090715_BrainampDBS_20150709_12.ds.zip - wires+ , movement+, stimulation+20Hz monopolarphantom090715_BrainampDBS_20150709_13.ds.zip - wires+ , movement+, stimulation+130Hz bipolarphantom090715_BrainampDBS_20150709_14.ds.zip - wires+ , movement+, stimulation+20Hz bipolarphantom090715_BrainampDBS_20150709_15.ds.zip - wires+ , movement+, stimulation+5Hz bipolarphantom090715_BrainampDBS_20150709_16.ds.zip - wires- , movement+, stimulation+20Hz monopolarphantom090715_BrainampDBS_20150709_17.ds.zip - wires- , movement+, stimulation+5Hz monopolarphantom090715_BrainampDBS_20150709_18.ds.zip - wires- , movement-, stimulation+5Hz monopolarphantom090715_BrainampDBS_20150709_20.ds.zip - wires- , movement-, stimulation+20Hz monopolar<br>phantom.mov - movie showing the phantom movementreadme.txt - this file<br>The MEG datasets also have accompanying BrainVision data sets where a copy of the 27 Hz sinusoid waveform fed to the phantom 'brain' source was stored. Since these are not required for testing artefact removal methods and using them would require merging with MEG we do not share them here but they could be provided on request. <br>This work was supported by the Medical Research Council and the National Institute for Health Research University College London Hospitals Biomedical Research Centre.The UK MEG community is supported by Medical Research Council grant MR/K005464/1. The Wellcome Trust Centre for Neuroimaging is supported by core funding from the Wellcome Trust 091593/Z/10/Z.<br>Please contact Vladimir Litvak [e-mail] for any additional information

本数据集源自一项实验，旨在测试脑深部刺激（Deep Brain Stimulation, DBS）伪迹对脑磁图（Magnetoencephalography, MEG）记录的影响，实验采用脑磁图仿真体（MEG phantom）开展。该实验的操作流程与实验结果已在以下文献中进行详细阐述与报道：
Oswal A, Jha A, Neal S, Reid A, Bradbury D, Aston P, Limousin P, Foltynie T, Zrinzo L, Brown P, Litvak V. 脑深部刺激期间同步脑磁图与颅内局部场电位（Local Field Potential, LFP）记录的分析：实验方案与验证. 神经科学方法杂志（J Neurosci Methods）. 2016年3月1日;261:29-46. DOI: 10.1016/j.jneumeth.2015.11.029. 2015年12月14日在线发表.

我们测试了多种不同的组合条件，涵盖铁磁连接导线的存在与否、模拟真实患者呼吸与心跳相关伪迹的肢体运动，以及两种刺激模式的脑深部刺激：双极刺激（仅引发微弱伪迹）与单极刺激（可引发严重伪迹）。具体实验细节请参见上述论文。

我们共测试了3种刺激频率：5Hz、20Hz及130Hz。

本次公开的数据集列表如下：
phantom090715_BrainampDBS_20150709_01.ds.zip：存在铁磁导线、无肢体运动、无刺激
phantom090715_BrainampDBS_20150709_02.ds.zip：无铁磁导线、无肢体运动、无刺激——该数据集为干净对照数据集，可作为参考基准
phantom090715_BrainampDBS_20150709_03.ds.zip：无铁磁导线、无肢体运动、130Hz单极刺激
phantom090715_BrainampDBS_20150709_04.ds.zip：无铁磁导线、存在肢体运动、130Hz单极刺激
phantom090715_BrainampDBS_20150709_05.ds.zip：无铁磁导线、无肢体运动、130Hz单极刺激
phantom090715_BrainampDBS_20150709_06.ds.zip：存在铁磁导线、无肢体运动、130Hz单极刺激
phantom090715_BrainampDBS_20150709_07.ds.zip：存在铁磁导线、存在肢体运动、130Hz单极刺激——该数据集为临床常用刺激频率下最贴近真实场景的数据集
phantom090715_BrainampDBS_20150709_08.ds.zip：存在铁磁导线、存在肢体运动、无刺激
phantom090715_BrainampDBS_20150709_09.ds.zip：存在铁磁导线、无肢体运动、20Hz单极刺激
phantom090715_BrainampDBS_20150709_10.ds.zip：存在铁磁导线、无肢体运动、5Hz单极刺激
phantom090715_BrainampDBS_20150709_11.ds.zip：存在铁磁导线、存在肢体运动、5Hz单极刺激
phantom090715_BrainampDBS_20150709_12.ds.zip：存在铁磁导线、存在肢体运动、20Hz单极刺激
phantom090715_BrainampDBS_20150709_13.ds.zip：存在铁磁导线、存在肢体运动、130Hz双极刺激
phantom090715_BrainampDBS_20150709_14.ds.zip：存在铁磁导线、存在肢体运动、20Hz双极刺激
phantom090715_BrainampDBS_20150709_15.ds.zip：存在铁磁导线、存在肢体运动、5Hz双极刺激
phantom090715_BrainampDBS_20150709_16.ds.zip：无铁磁导线、存在肢体运动、20Hz单极刺激
phantom090715_BrainampDBS_20150709_17.ds.zip：无铁磁导线、存在肢体运动、5Hz单极刺激
phantom090715_BrainampDBS_20150709_18.ds.zip：无铁磁导线、无肢体运动、5Hz单极刺激
phantom090715_BrainampDBS_20150709_20.ds.zip：无铁磁导线、无肢体运动、20Hz单极刺激
phantom.mov：展示仿真体运动的视频文件
readme.txt：本文档

本数据集附带的BrainVision数据集中存储了输入至仿真体“脑”信号源的27Hz正弦波形副本。由于该类数据无需用于伪迹去除方法的测试，且需与脑磁图数据进行合并后方可使用，因此本次未公开共享，如有需求可联系获取。

本研究得到了医学研究理事会（Medical Research Council）与英国国民保健署大学学院伦敦医院生物医学研究中心的资助。英国脑磁图社区的工作得到了医学研究理事会项目MR/K005464/1的支持。惠康信托基金神经成像中心的运营得到了惠康信托基金核心资助091593/Z/10/Z。

如需获取更多信息，请联系弗拉基米尔·利特瓦克（Vladimir Litvak），邮箱：[e-mail]。