Locus Coeruleus firing patterns selectively modulate brain activity and dynamics

This dataset supports the manuscript entitled 'Locus Coeruleus firing patterns selectively modulate brain activity and dynamics' (https://doi.org/10.1101/2022.08.29.505672). Please refer to this manuscript for detailed information. 

The dataset contains a total of 81 functional (GE-BOLD) and 30 anatomical (T1-weighted) scans of ChR2-expressing C57BL/6-Tg(Dbh-iCre)1Gsc mice in NIFTI format, multiplied by 10. Mice were optogenetically stimulated with blue light in the right Locus Coeruleus in a 3Hz tonic, 5Hz tonic, and 15Hz burst pattern. Sham stimulation entailed red light stimulation at a 5Hz tonic frequency. The 'StimulationProtocol' text file specifies the precise onset (in seconds, minus 10 seconds for dummy scans) and duration (in seconds) of the different optogenetic stimulation protocols during a 1440 seconds functional scan. The 'SubjectDetails' file lists the subject IDs, their gender, their genotype, the stimulation type of functional scans, and their associated anatomical scan.

本数据集支持题为《蓝斑（Locus Coeruleus）放电模式选择性调控脑活动与脑动态特性》的研究手稿（https://doi.org/10.1101/2022.08.29.505672），详细信息请参阅该手稿。

本数据集共包含81份功能（GE-BOLD）扫描与30份解剖（T1加权）扫描数据，均来自表达光敏感通道蛋白ChR2（Channelrhodopsin-2）的C57BL/6-Tg(Dbh-iCre)1Gsc小鼠，所有扫描均采用NIFTI格式存储，且每份数据经10次重复采集。研究人员对小鼠右侧蓝斑（Locus Coeruleus）施以蓝光光遗传刺激，刺激模式分为3Hz紧张式、5Hz紧张式与15Hz爆发式；假刺激组则采用5Hz紧张式红光刺激。

'StimulationProtocol'文本文件明确了1440秒功能扫描过程中，各光遗传刺激方案的精准起始时间（单位为秒，需扣除预扫描的10秒）与持续时长（单位为秒）。'SubjectDetails'文件则列出了所有受试者的编号、性别、基因型、功能扫描对应的刺激类型，以及与之匹配的解剖扫描信息。