Leucine-rich repeat (LRR) proteins play contrasting roles in the choice between normal and melanized parasite fates.

A. The activity of APL1C but not LRR7037 restricts permissiveness of mosquitoes to P. yoelii infection, measured as oocyst infection prevalence. B. APL1C function also limits the efficiency of parasite development within infected mosquitoes, measured as infection intensity. LRR7059 and LRR7037 have no effect (S2 Table). C. Loss of function of either APL1C or LRR7037 is accompanied by reduced levels of parasite melanization. In the absence of APL1C activity, the non-melanized parasites appear to develop normally (compare C with A), while in the absence of LRR7037 activity, the non-melanized parasites nevertheless are apparently still killed. Graph labels and statistical tests as in Fig 2 legend.

A. 以卵囊感染率为检测指标，APL1C而非LRR7037的活性可限制蚊子对约氏疟原虫（Plasmodium yoelii，P. yoelii）感染的易感性。
B. APL1C的功能同样可抑制受感染蚊子体内寄生虫的发育效率，该指标以感染强度衡量。LRR7059与LRR7037无此调控作用（附表S2）。
C. APL1C或LRR7037的功能缺失均会导致寄生虫黑化反应水平降低。在APL1C活性缺失的条件下，未发生黑化的寄生虫似乎可正常发育（将C组与A组对比）；而在LRR7037活性缺失时，未黑化的寄生虫仍会被显著清除。图表标注及统计学检验方法同图2图例。