Table 1_Fast food consumption and risk of non-alcoholic fatty liver disease: a systematic review and meta-analysis.docx

BackgroundNon-alcoholic fatty liver disease (NAFLD) is a global health issue, with fast food consumption hypothesized as a risk factor. This meta-analysis aimed to explore the relationship between fast food intake and NAFLD.
MethodsThis review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. A comprehensive search was conducted across PubMed, Web of Science, Scopus, and Embase from inception to February 28, 2025. A total of nine eligible observational studies involving 169,771 participants were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random-effects models.
ResultsA higher consumption of fast food was significantly associated with a 55% increased risk of NAFLD (OR = 1.55, 95% CI: 1.51–1.59, p < 0.001, I2 = 15.6%). Moreover, fast food intake was linked to a 37% higher risk of obesity (OR = 1.37, 95% CI: 1.27–1.49, p < 0.001, I2 = 54.2%), a key metabolic factor in NAFLD pathogenesis. Sensitivity analysis confirmed the robustness of these associations, with no significant evidence of publication bias.
ConclusionFast food consumption is positively associated with NAFLD and obesity. Heterogeneity highlights the need for standardized methods in future large-scale studies to validate these findings and inform preventive strategies.

背景：非酒精性脂肪性肝病（Non-alcoholic fatty liver disease, NAFLD）是一项全球公共卫生问题，现有假说认为快餐摄入是其潜在危险因素。本荟萃分析旨在探讨快餐摄入与非酒精性脂肪性肝病之间的关联。
方法：本综述严格遵循《系统评价与荟萃分析首选报告条目（PRISMA）2020版》指南开展。研究于各数据库建库时至2025年2月28日，在PubMed、Web of Science、Scopus及Embase数据库中开展全面检索。最终纳入9项符合纳入标准的观察性研究，共涉及169771名研究对象。采用随机效应模型计算合并比值比（OR）及95%置信区间（CI）。
结果：较高的快餐摄入水平与非酒精性脂肪性肝病风险升高55%显著相关（OR=1.55，95%CI：1.51~1.59，P<0.001，I²=15.6%）。此外，快餐摄入还与肥胖风险升高37%相关（OR=1.37，95%CI：1.27~1.49，P<0.001，I²=54.2%），而肥胖是非酒精性脂肪性肝病发病机制中的关键代谢因素。敏感性分析证实上述关联具有稳健性，未发现显著的发表偏倚证据。
结论：快餐摄入与非酒精性脂肪性肝病及肥胖均呈正相关。本研究存在的异质性提示，未来需开展采用标准化方法学的大规模研究，以验证本研究结论并为疾病预防策略制定提供依据。