RNAseq analysis of protein expression in synovial tissue of control or model rats (CIA model) in wildtype rat group or CD47 knockout group

To see protein expression on an mRNA level in rat synovial tissue in four groups of rats (wildtype normal, CD47 knockout normal, wildtype model, CD47 knockout model). Model means collagen-induced arhtritis in rats. To see the important role of CD47 in the development of rheumatoid arthritis. To see the mechanism for CD47 knockout to alleviate RA symptom by measuring the expression of CD47 and related molecules in wildtype and CD47 knockout model rat synivial tissue in comparison with wildtype and CD47 knockout normal rats.

本数据集旨在检测四组大鼠（野生型（wildtype）正常组、CD47基因敲除（CD47 knockout）正常组、野生型模型组、CD47基因敲除模型组）滑膜组织中mRNA水平的蛋白质表达情况。其中，模型组指构建了胶原诱导性关节炎（collagen-induced arthritis）模型的大鼠。本研究同时旨在明确CD47在类风湿关节炎（rheumatoid arthritis, RA）发病进程中的关键作用，并通过对比野生型、CD47基因敲除正常大鼠与对应模型组大鼠滑膜组织内CD47及相关分子的表达水平，解析CD47基因敲除缓解类风湿关节炎症状的分子机制。