High susceptible model of SARS-CoV2 in CAG promoter-driven hACE2 transgenic mice. Mus musculus

COVID-19, caused by SARS-CoV-2, has spread worldwide with a dire disaster situation. To urgently investigate the pathogenicity of COVID-19 and develop vaccines and therapeutics, animal models that are highly susceptible to SARS-CoV-2 infection are needed. In the present study, we established an animal model highly susceptible to SARS-CoV-2 via the intratracheal tract infection in CAG-promoter-driven human angiotensin-converting enzyme 2 transgenic (CAG-hACE2) mice.

由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引发的新型冠状病毒肺炎（COVID-19）已在全球范围内蔓延，疫情态势极为严峻。为迫切探究COVID-19的致病性并开发疫苗与治疗药物，亟需构建对SARS-CoV-2感染高度易感的动物模型。本研究通过气管内感染途径，在CAG启动子驱动的人血管紧张素转换酶2转基因（CAG-hACE2）小鼠中，成功建立了对SARS-CoV-2高度易感的动物模型。