Single-cell or nucleus RNAseq of neuroblastoma patient-derived xenografts

Gene expression profile at single cell level of 17 orthotopic-patient derived xenografts from neuroblastoma samples. All xenografts were obtained through the St. Jude Childhood Solid Tumor Network (https://cstn.stjude.cloud/) Overall design: 15 samples underwent single-nucleus RNA-sequencing, and 2 samples underwent single-cell RNA-sequencing. Fastq files were aligned to a combined human and mouse reference (GRCh38-and-mm10).

本数据集涵盖17株来源于神经母细胞瘤（neuroblastoma）样本的原位患者来源异种移植瘤（orthotopic-patient derived xenografts）的单细胞水平基因表达谱。所有异种移植瘤均通过圣犹大儿童实体瘤网络（St. Jude Childhood Solid Tumor Network，https://cstn.stjude.cloud/）获取。实验整体设计：15份样本进行单细胞核RNA测序（single-nucleus RNA-sequencing），剩余2份样本进行单细胞RNA测序（single-cell RNA-sequencing）。所有Fastq文件均比对至人类与小鼠的联合参考基因组（GRCh38与mm10）。