Dnmt3a Regulates T-cell Development and Suppresses T-ALL Transformation (RNA-seq)

Gene expression analysis of T-cell acute lymphoblastic leukemia blast cells from either control mice or Dnmt3a knockout mice carrying a Notch1 Intracellular Domain (NICD) retrovirus Comparison of gene expression between control and Dnmt3a-KO NICD-driven T-ALL本数据集针对T细胞急性淋巴细胞白血病（T-cell acute lymphoblastic leukemia, T-ALL）母细胞开展基因表达分析，两类细胞分别分离自对照小鼠，以及携带Notch1胞内域（Notch1 Intracellular Domain, NICD）逆转录病毒的Dnmt3a敲除小鼠；同时对对照小鼠来源T-ALL与Dnmt3a-KO NICD驱动的T-ALL进行基因表达差异比较。