Systemic Therapy in Combination With Stereotactic Radiotherapy in Patients With Metastatic Colorectal Cancer up to 10 Metastatic Sites

A small number of colorectal cancer patients with limited oligometastases may be candidates for local treatment of metastases (e.g., resection, ablation). However, it is unclear if patients with more extensive metastatic disease benefit from local therapies to control visible metastasis.
The purpose of this study is to assess the impact of stereotactic body radiation therapy (SBRT) in combination with systemic therapy compared to systemic therapy alone on safety and efficacy in patients with metastatic colorectal cancer (mCRC) and ≤10 metastases.

少数存在局限性寡转移（oligometastases）的结直肠癌患者，可作为转移灶局部治疗（如切除术、消融术）的候选人群。不过，针对转移范围更广泛的患者，局部治疗能否使其在控制可见转移灶方面获益，目前尚不明确。
本研究旨在评估，针对转移性结直肠癌（metastatic colorectal cancer, mCRC）且转移灶数量≤10个的患者，体部立体定向放射治疗（stereotactic body radiation therapy, SBRT）联合全身治疗，对比单纯全身治疗的安全性与有效性。