Hematological change parameters in patients with pressure ulcer at long-term care hospital

Objective To assess factors associated with the development of pressure ulcers, and to compare the effectiveness of pharmacological treatments. Methods The factors associated with the development of pressure ulcers were compared in lesion-carrying patients (n=14) and non-carriers (n=16). Lesion-carrying patients were treated with 1% silver sulfadiazine or 0.6IU/g collagenase and were observed for 8 weeks. The data collected was analyzed with p<0.05 being statistically relevant. Results The prevalence of pressure ulcers was about 6%. The comparison of carrier and non-carrier groups of pressure ulcers revealed no statistically significant difference in its occurrence with respect to age, sex, skin color, mobility, or the use of diapers. However, levels of hemoglobin, hematocrit, and red blood cells were found to be statistically different between groups, being lower in lesion-carrying patients. There was no significant difference found in lesion area between patients treated with collagenase or silver sulfadiazine, although both groups showed an overall reduction in lesion area through the treatment course. Conclusion Hematologic parameters showed a statistically significant difference between the two groups. Regarding the treatment of ulcers, there was no difference in the area of the lesion found between the groups treated with collagenase and silver sulfadiazine.

研究目的：评估与压疮（pressure ulcer）发生相关的影响因素，并比较不同药物治疗方案的临床有效性。研究方法：本研究纳入压疮携带患者（n=14）与非携带患者（n=16），对比压疮发生的相关影响因素。压疮携带患者分别接受1%磺胺嘧啶银（silver sulfadiazine）或0.6IU/g胶原酶（collagenase）治疗，随访观察8周。所有收集的数据以P<0.05作为统计学显著性阈值进行分析。研究结果：压疮患病率约为6%。对比压疮患者与非患者群体的各项指标发现，两组在年龄、性别、肤色、活动能力或尿布使用情况等方面的压疮发生率均无统计学差异。但两组的血红蛋白（hemoglobin）、红细胞比容（hematocrit）及红细胞（red blood cells）水平存在显著统计学差异，压疮患者的上述指标均低于非患者组。接受胶原酶与磺胺嘧啶银治疗的患者，其创面面积无显著统计学差异，尽管两组在整个治疗周期内的创面面积均呈现整体下降趋势。研究结论：两组患者的血液学参数存在显著统计学差异。在压疮治疗方面，胶原酶与磺胺嘧啶银治疗组的创面面积无显著差异。