Genomic insights of the globally disseminated multidrug-resistant K. pneumoniae Clonal Group 147

In this study, we describe a pandrug resistant ST147 Kp clinical isolate from India exploring the genetics mechanism behind the observed phenotypic profile. Furthermore, we investigated the genomic insights of 218 K. pneumoniae CG147 whole-genome sequences publicly available in order to provide a deeper understanding of the evolution and global molecular epidemiology (phylogeny, antimicrobial resistance and virulence genes, plasmid profiles) of this increasingly successful MDR worldwide lineage.

本研究针对一株源自印度的泛耐药序列型147（ST147）肺炎克雷伯菌（Klebsiella pneumoniae，简称Kp）临床分离株展开分析，旨在解析其观测表型背后的遗传机制。此外，本研究对公共数据库中公开可获取的218株肺炎克雷伯菌克隆群147（CG147）全基因组序列开展基因组学研究，以期更深入地理解这一在全球范围内日益流行的多重耐药（Multidrug Resistance，简称MDR）谱系的演化特征与全球分子流行病学规律，涵盖其系统发育、抗菌耐药基因、毒力基因及质粒图谱。