Mutagenesis in POLH knockout cell line

We generated POLH knockouts in RPE-1 cell line to better understand mutagenesis in xeroderma pigmentosum variant (XP-V) patients.本研究在RPE-1细胞系中构建了POLH基因敲除细胞（POLH knockouts），以更深入地解析着色性干皮病变异型（XP-V）患者体内的诱变机制。