Additional file 1 of Prognostic value of functional SMAD4 localization in extrahepatic bile duct cancer

Additional file 1: Supplemental Figure 1. Histogram of the SMAD4 immunohistochemical score for resected specimens. Supplemental Figure 2. Kaplan-Meier survival curves for 67 patients with SMAD4 expression at either the central lesion or invasion front stratified by the SMAD4 status in each area. Supplemental Figure 3. Kaplan-Meier survival curves for 73 patients who underwent upfront surgery stratified by treatment with adjuvant chemotherapy. Supplemental Figure 4. Kaplan-Meier survival curves for patients who underwent upfront surgery stratified by treatment with adjuvant chemotherapy. Supplemental Figure 5. Kaplan-Meier survival curves for patients who underwent upfront surgery stratified by treatment with adjuvant chemotherapy. Supplemental Figure 6. Kaplan-Meier survival curves for 98 patients stratified by neoadjuvant treatment.附加文件1： 补充图1：手术切除标本的SMAD4免疫组织化学评分直方图。 补充图2：针对67例在病灶中心或侵袭前沿表达SMAD4的患者，按各区域SMAD4状态分层的卡普兰-迈耶生存曲线（Kaplan-Meier）。 补充图3：针对73例接受先行手术的患者，按辅助化疗治疗情况分层的卡普兰-迈耶生存曲线。 补充图4：针对接受先行手术的患者，按辅助化疗治疗情况分层的卡普兰-迈耶生存曲线。 补充图5：针对接受先行手术的患者，按辅助化疗治疗情况分层的卡普兰-迈耶生存曲线。 补充图6：针对98例患者，按新辅助治疗情况分层的卡普兰-迈耶生存曲线。