HIV Oral Bacterial Microbiome. HIV Oral Bacterial Microbiome

Changes in human oral microbiota have been linked to diseases of aging that are common in HIV, including atherosclerosis and certain cancers. Oral pathology, including thrush, oral hairy leukoplakia and periodontal disease, is common in chronic HIV infection. HIV has been associated with shifts in the microbiome at several sites, although no studies have longitudinally assessed oral microbiome change in the setting of controlled ART initiation. Here, we characterize the oral bacterial microbiome before and after 24 weeks of ART.

人类口腔微生物群（human oral microbiota）的变化与HIV感染者常见的衰老相关疾病存在关联，这类疾病包括动脉粥样硬化（atherosclerosis）和部分恶性肿瘤。慢性HIV感染者常出现多种口腔病理表现，包括鹅口疮（thrush）、口腔毛状白斑（oral hairy leukoplakia）以及牙周疾病（periodontal disease）。尽管目前尚无研究在规范启动抗逆转录病毒治疗（Antiretroviral Therapy，ART）的背景下对口腔微生物组的变化开展纵向评估，但已有研究证实HIV与多个身体部位的微生物组组成偏移存在关联。本研究对接受ART治疗前及治疗24周后的口腔细菌微生物组进行了系统的特征解析。