ATN 004 Scaled Measures Derived From CAPI Datasets Dataset in Healthy Choices: Motivational Enhancement to Promote Health and Reduce Risk in HIV-Infected Youth

Data from Scaled Measures Derived From CAPI Datasets
Study Description
In this Phase II multi-site clinical trial, HIV+ youth were randomized to receive either a four-session motivational enhancement intervention and referrals or standard care plus referrals. Participants randomized to the intervention group participated in four sessions of Healthy Choices, a motivational enhancement intervention specifically designed to target multiple risk behaviors in HIV+ youth. Participants received individualized referrals at the fourth session. Participants randomized to standard care also received individualized referrals. Interviews, self-report, chart review and blood tests were used to measure substance use, condom use, adherence to medications, and health outcomes, as well as hypothesized mediators and moderators of the intervention. The primary objective was to determine the efficacy of a motivational enhancement intervention in reducing health risk behaviors (drug and alcohol use, sexual risk behavior, poor adherence to medications) among HIV+ youth. HIV+ youth ages 16 to 24 years, engaged in two out of three problem behaviors (substance use, sexual risk behavior, or poor medication adherence)

源自计算机辅助个人访谈（Computer-Assisted Personal Interviewing, CAPI）数据集的标准化测量数据

研究概况

本项II期多中心临床试验中，HIV阳性青少年被随机分配至两组：一组接受四疗程动机强化干预联合转介服务，另一组仅接受标准治疗联合转介服务。其中，干预组参与者将参与四疗程的「健康选择」（Healthy Choices）动机强化干预方案——该方案专为针对HIV阳性青少年的多重风险行为设计，参与者将在第四疗程中获得个性化转介服务；标准治疗组参与者同样可获得个性化转介服务。

本研究通过访谈、自我报告、病历回顾以及血液检测，对物质使用、安全套使用、药物依从性与健康结局进行评估，同时对该干预的潜在中介变量与调节变量进行测量。本研究的主要目的为评估动机强化干预方案在降低HIV阳性青少年健康风险行为（药物与酒精使用、性风险行为、药物依从性不佳）方面的有效性。本研究纳入年龄介于16至24岁的HIV阳性青少年，且存在三类问题行为中的两类：物质使用、性风险行为或药物依从性不佳。