Using single-cell RNA-Seq for unbiased analysis of developmental hierarchies (single cell RNA Seq of bone marrow lineage-negative CD117+ CD34+ cells)

Single cell RNA seq and bioinformatic analysis is used to characterize myeloid differentiation to uncover novel transcriptional networks and key drivers of hematoipoietic development Overall design: Single cell RNA seq of different hematopoietic populations integrated with Chip seq involving multiple markers

本研究通过单细胞RNA测序（Single cell RNA seq）与生物信息学分析对髓系分化进行特征表征，以揭示造血发育过程中全新的转录调控网络与关键驱动因子。
整体实验设计：对不同造血细胞群体开展单细胞RNA测序，并整合包含多种标记物的染色质免疫共沉淀测序（ChIP seq）数据。