Dietary fatty acids interact with gut microbiota and TLR4 to promote colitis and colorectal tumorigenesis

We show that oxidized LA, rather than LA itself,exacerbates colitis via Toll-like receptor 4 (TLR4)- and gut microbiota-dependent mechanisms.Administration of a diet containing oxidized LA, at low human-consumption levels, increases the severity of colitis and exacerbates the development of colorectal tumorigenesis in mice. To prepare “un-oxidized corn oil”, freshly opened commercial samples of corn oil were purified by column chromatography.

本研究证实，相较于亚油酸（LA）本身，氧化型亚油酸可通过依赖于Toll样受体4（TLR4）与肠道菌群的机制加重结肠炎。以接近人类日常摄入水平的剂量给小鼠喂食含有氧化型亚油酸的饲料，会加剧结肠炎的严重程度，并加重小鼠结直肠肿瘤的发生发展。为制备“未氧化玉米油”，研究人员对刚开封的市售玉米油样品采用柱层析法进行纯化。