HAMLET, a human milk protein-lipid complex, modulates amoxicillin-induced changes in an ex vivo biofilm model of the oral microbiome

Challenges from infections caused by biofilms and antimicrobial resistance highlight the need for novel antimicrobials that work synergistically with antibiotics and minimize resistance risk. In this study, authors investigated the potential synergistic effect of HAMLET (human alpha-lactalbumin made lethal to tumor cells), found in human milk protein-lipid complex, and amoxicillin on the microbial ecology of an ex-vivo human model of oral biofilm model using a whole metagenomics approach.

生物膜感染与抗菌药物耐药性带来的挑战，凸显了研发可与抗生素协同作用并降低耐药风险的新型抗菌剂的迫切需求。本研究中，研究者采用全宏基因组学分析方法，探究了人乳蛋白-脂质复合物中提取的HAMLET（人α-乳清蛋白，可杀伤肿瘤细胞，human alpha-lactalbumin made lethal to tumor cells）与阿莫西林对离体人体口腔生物膜模型的微生物生态学的潜在协同效应。