RNA-seq of Streptococcus equi strains with and without csrRS SNPs

CsrRS is a two component regulator which is known to regulate 10-18 % of the genome of the closely related Streptococcus pyogenes. We aimed to look for transcriptional differences between pairs of naturally occurring Streptococcus equi strains where one possessed a SNP in csrRS whereas the other did not. Such SNPs have not been identified in isolates from acute disease but have been identified in persistent isolates.CsrRS是一种双组分调控系统，据报道可调控亲缘关系紧密的化脓性链球菌（Streptococcus pyogenes）10%~18%的基因组。本研究旨在探究一对天然存在的马链球菌（Streptococcus equi）菌株间的转录差异：其中一株的csrRS基因携带单核苷酸多态性（Single Nucleotide Polymorphism，SNP），另一株则无此变异。此类单核苷酸多态性尚未在急性疾病分离株中被检出，但已在持续性感染分离株中得到鉴定。