Cell envelope gene KDs develop strong fitness changes against Tae1 in competition.

KDs that target PG synthesis can increase PaeWT sensitivity, while targeting other cell envelope processes can result in sensitivity or resistance. Data shown: normalized L2FC values for all 20 KD strains with unique and significant fitness changes against PaeWT (which secretes Tae1); average of four biological replicates.

靶向肽聚糖（peptidoglycan, PG）合成的基因敲低（knockdown, KD）可提升铜绿假单胞菌野生型（Pseudomonas aeruginosa wild-type, PaeWT）的敏感性；而靶向其他细胞包膜过程的基因敲低，则可导致敏感性改变或产生抗性。本次展示的数据为全部20株携带独特且显著适应性变化的基因敲低菌株，在针对分泌Tae1的铜绿假单胞菌野生型时的标准化L2FC（normalized log2 fold change）值，该值为四次生物学重复的平均值。