Roux-en-Y gastric bypass surgery of morbidly obese patients shows swift and persistent changes of the individual gut microbiota. GBP

Roux-en-Y gastric bypass (RYGB) is an effective means to achieve sustained weight loss for morbidly obese individuals. Besides rapid weight reduction, patients achieve major improvements of insulin sensitivity and glucose homeostasis. Dysbiosis of gut microbiota has been associated with obesity and some of its co-morbidities like type 2 diabetes, and major changes of gut bacterial communities have been hypothesized to mediate part of the beneficial metabolic effects observed after RYGB. This study we describe changes in gut microbial taxonomic composition and functional potential following RYGB.

鲁氏Y形胃旁路术（Roux-en-Y gastric bypass, RYGB）是帮助病态肥胖患者实现持续性体重减轻的有效手段。除快速减重外，患者的胰岛素敏感性与血糖稳态可获得显著改善。肠道菌群失调与肥胖及其部分合并症（如2型糖尿病）存在相关性，而肠道菌群群落的显著变化被推测可介导RYGB术后观察到的部分有益代谢效应。本研究阐述了RYGB术后肠道微生物群的分类学组成与功能潜能的变化情况。