Semi-simulated TF pertubation in ATAC-seq datasets (GC content bias)

Semi-simulated ATAC-seq data with TF pertubations of different pertubation strength & GC content biases. The three .tar-files contain: 

DTFAB_sim_gc_beds.tar.gz: .bed files of the semi-simulated ATAC-seq fragments

DTFAB_sim_gc_cm.tar.gz: count matrices (per peak counts of semi-simulated fragments)

DTFAB_sim_gc_peaks.tar.gz: .bed files with ATAC-seq peak coordinates of semi-simulated fragments

The folder structure of 1.,2. & 3. is of the following format ___FALSE_. The original files, for which biases & pertubations were introduced, were retrieved from ENCODE with following IDs: ENCFF495DQP, ENCFF130DND, ENCFF447ZRG, ENCFF966ELR, ENCFF358GWK, ENCFF963YZH. ChIP-seq peaks used to introduce perturbations correspond to following ENCODE identifiers: ENCFF592UDD, ENCFF250FJC.

This semi-simulated datasets is belongs to a series of datasets: 

Dataset
Description
DOI

I. pertubation strength
TF pertubation with different strengths, no biases introduced
10.5281/zenodo.10732704

II. pos control
TF pertubation only introduced in (ChIP-) peaks with a motif of the respective TF.
10.5281/zenodo.10781849

III. fld
TF pertubation with additionally introduced fragment length distribution bias
10.5281/zenodo.10781109

IV. gc (this)
TF pertubation with additionally introduced GC content bias
10.5281/zenodo.10781759

带有不同扰动强度与GC含量偏倚的转录因子（Transcription Factor, TF）扰动的半模拟转座酶可及性染色质测序（ATAC-seq）数据。其包含三个.tar压缩包，具体内容如下：

DTFAB_sim_gc_beds.tar.gz：存储半模拟ATAC-seq片段的.bed格式文件
DTFAB_sim_gc_cm.tar.gz：存储计数矩阵（半模拟片段的每峰计数结果）
DTFAB_sim_gc_peaks.tar.gz：存储包含半模拟片段ATAC-seq峰坐标的.bed格式文件

上述1至3项的文件夹结构遵循格式___FALSE_。用于引入偏倚与扰动的原始数据从ENCODE数据库获取，对应的编号为：ENCFF495DQP、ENCFF130DND、ENCFF447ZRG、ENCFF966ELR、ENCFF358GWK、ENCFF963YZH。用于引入扰动的ChIP-seq峰对应的ENCODE标识符为：ENCFF592UDD、ENCFF250FJC。

本半模拟数据集隶属于以下数据集系列：

I. 扰动强度系列：施加不同强度的TF扰动，未引入任何偏倚，DOI：10.5281/zenodo.10732704
II. 阳性对照：仅在对应TF基序的（ChIP）峰中引入TF扰动，DOI：10.5281/zenodo.10781849
III. 片段长度分布偏倚系列：额外引入片段长度分布偏倚的TF扰动数据集，DOI：10.5281/zenodo.10781109
IV. GC含量偏倚系列（本数据集）：额外引入GC含量偏倚的TF扰动数据集，DOI：10.5281/zenodo.10781759