Molecular subtypes of malignant peritoneal mesothelioma

Malignant Peritoneal Mesothelioma (PeM) is a rare but frequently fatal cancer that originates from the peritoneal lining of the abdomen. Standard treatment of PeM is limited to cytoreductive surgery and/or chemotherapy, and no targeted therapies for PeM yet exist. This study performs comprehensive integrative analysis of genome, transcriptome, and proteome of treatment-naïve PeM tumors with the aim of identifying mesothelioma-related molecular alterations and potentially identifying novel treatment strategies.

恶性腹膜间皮瘤（Malignant Peritoneal Mesothelioma，PeM）是一种罕见但多为致死性的恶性肿瘤，起源于腹部腹膜内层组织。目前针对该疾病的标准治疗手段仅局限于肿瘤细胞减灭术联合或单独化疗，尚未有获批的靶向治疗方案。本研究对未经治疗的PeM肿瘤样本开展基因组（genome）、转录组（transcriptome）及蛋白质组（proteome）的综合整合分析，旨在挖掘与间皮瘤相关的分子异常特征，并有望探索新型治疗策略。