Data from: Amadori-glycated phosphatidylethanolamine enhances the physical stability and selective targeting ability of liposomes

Liposomes comprised of 100% phosphatidylcholine exhibit poor membrane fusion, cellular uptake, and selective targeting capacities. To overcome these limitations, we used Amadori-glycated phosphatidylethanolamine, which is universally present in animals and commonly consumed in foods. We found that liposomes containing Amadori-glycated phosphatidylethanolamine exhibited significantly reduced negative membrane potential and demonstrated high cellular uptake.

完全由磷脂酰胆碱（phosphatidylcholine）构成的脂质体，其膜融合、细胞摄取以及靶向选择性能力均较差。为克服上述局限性，我们采用了阿马多里糖基化磷脂酰乙醇胺（Amadori-glycated phosphatidylethanolamine）——该物质广泛存在于动物体内且常见于日常膳食中。研究发现，搭载阿马多里糖基化磷脂酰乙醇胺的脂质体，其膜负电位显著降低，同时展现出优异的细胞摄取效果。