RovHer: heritability-optimized scores for the functional prioritization of rare missense variants

A heritability-optimized scoring method using multivariate adaptive regression splines that incorporates 75 variant- and gene-level features. RovHer leverages exome-wide association statistics to train models estimating the probability of RV functional impact.一种基于多变量自适应回归样条（Multivariate Adaptive Regression Splines）的遗传力优化评分方法，整合了75项变异位点与基因水平特征。RovHer借助全外显子组关联统计量训练模型，以估算罕见变异（Rare Variant, RV）的功能影响概率。