ALVEOLAR BONE PATTERN AND SALIVARY LEPTIN LEVELS AMONG PREMENOPAUSAL OBESE WOMEN

ABSTRACT Background: Systemic bone loss may lead to more severe periodontal destruction, decreasing local bone mineral density. Aim: A cross-sectional designed was performed to study associations among alveolar bone pattern, salivary leptin concentrations, and clinical periodontal status in premenopausal obese and eutrophic women. Methods: Thirty morbid obese (G1) and 30 normal-weight (G2) women were included. Anthropometric and periodontal measurements (probing depth - PD, clinical attachment levels - CAL, presence of calculus, bleeding on probing -BOP, and plaque accumulation) were assessed. OHIP-14 was used for assessment of oral health impact on quality of life. Panoramic radiography was used to obtain the panoramic mandibular index (PMI), mandibular cortical index (MCI), and mental index (MI). Intraoral periapical (PA) radiography was taken to measure the total trabecular bone volume. Leptin was measured in saliva of fasted overnight women. Results: Groups 1 and 2 differed in all anthropometric aspects, but height. Pocket depth, calculus, BOP, and plaque index were worse in G1. No differences between groups were found considering OHIP. Normal-weight subjects showed higher proportion of dense bone trabeculae than obese subjects for pre-molars, but not for molars. Mental and panoramic mandibular indexes did not differ and were in normal level. Leptin concentration was dependent only on BMI. Conclusion: Obesity affected the periodontal conditions, the alveolar bone pattern, and the salivary leptin concentration.

摘要
研究背景：全身性骨丢失可加重牙周组织破坏，降低局部骨密度。
研究目的：本研究采用横断面设计，探讨绝经前肥胖与体质量正常女性的牙槽骨形态、唾液瘦素浓度与临床牙周状态之间的关联。
研究方法：纳入30例病态肥胖女性（G1组）与30个体质量正常女性（G2组）。采集人体测量学指标与牙周相关检测数据，包括探诊深度（PD）、临床附着水平（CAL）、牙结石检出情况、探诊出血（BOP）及菌斑堆积情况。采用口腔健康影响量表14（OHIP-14）评估口腔健康对生活质量的影响。通过曲面全景放射摄影术获取曲面全景下颌指数（PMI）、下颌骨皮质指数（MCI）及颏孔区指数（MI）；采用口内根尖片（PA）摄影术测量骨小梁总体积。采集隔夜禁食女性的唾液样本以检测瘦素水平。
研究结果：两组在所有人体测量学指标上均存在显著差异，仅身高除外。G1组的探诊深度、牙结石检出情况、探诊出血及菌斑指数均差于G2组。两组在OHIP-14评分上无显著差异。体质量正常者前磨牙区的骨小梁致密比例高于肥胖者，但磨牙区无此差异。颏孔区指数与曲面全景下颌指数无组间差异，且均处于正常水平。唾液瘦素浓度仅与体质量指数（BMI）相关。
研究结论：肥胖可影响牙周状态、牙槽骨形态及唾液瘦素浓度。