Comparative genomics of blaNDM-1-producing Escherichia coli ST101 isolates. Escherichia coli strain:MS6201

Extraintestinal pathogenic Escherichia coli (ExPEC) are the leading cause of urinary and systemic infections, where antibiotic resistance complicates successful treatment. Carbapenems are considered a last-resort antibiotic, however the spread of plasmid-encoded carbapenemases such as the New-Delhi Metallo-beta-Lactamase (blaNDM-1) challenges their effectiveness. E. coli ST101 is an emerging, atypical multidrug resistant ExPEC lineage, highly associated with the carriage of blaNDM-1. In this study we analysed the phylogeny and antimicrobial resistance of ST101 isolates from the UK and India.

肠外致病性大肠杆菌（Extraintestinal pathogenic Escherichia coli, ExPEC）是引发泌尿系统与全身性感染的首要致病菌，抗生素耐药性会为这类感染的成功治疗带来极大挑战。碳青霉烯类抗生素被视作临床最后一线抗菌药物，然而质粒编码的碳青霉烯酶——如新德里金属β-内酰胺酶（blaNDM-1）的传播，却削弱了其临床疗效。大肠杆菌ST101是一种新兴的非典型多重耐药ExPEC谱系，与blaNDM-1的携带状态高度相关。本研究针对来自英国与印度的ST101分离株，对其系统发育特征与抗菌药物耐药性展开了分析。