Correlation between parameters of self-monitoring of blood glucose and the perception of health-related quality of life in patients with type 1 diabetes mellitus

ABSTRACT Objective The aim of this study was to evaluate how different parameters of short-term glycemic control would correlate with the perception of health-related quality of life (HRQoL) in patients with type 1 diabetes mellitus (T1D). Subjects and methods A total of 50 T1D patients aged 18 to 50 years were evaluated with the questionnaires Problem Areas in Diabetes (PAID) scale and Diabetes Quality of Life (DQOL) measure after 30 days of self-monitoring of blood glucose (SMBG). Glycemic control was evaluated using glycated hemoglobin (HbA1c), mean glucose levels (MGL) in the prior month’s data from SMBG (Accu-Check 360o), number of hypoglycemic episodes (< 70 mg/dL and < 50 mg/dL), and glycemic variability (GV). Results PAID correlated positively with MGL (r = 0.52; p < 0.001) and HbA1c (r = 0.36; p < 0.0097), but not with GV (r = 0.17; p = 0.23) or number of hypoglycemic episodes (r = 0.15; p = 0.17 for glucose < 70 mg/dL and r = 0.02; p = 0.85 for glucose < 50 mg/dL). After multiple linear regression, only MGL remained independently related to PAID scores. DQOL scores had a positive correlation with MGL (r = 0.45; p = 0.001), but not with HbA1c (r = 0.23; p = 0.09), GV (r = 0.20; p = 0.16), or number of hypoglycemic episodes (r = 0.06 p = 0.68). Conclusion In T1D patients, MGL, but not HbA1c or number hypoglycemic episodes, was the glycemic control parameter that best correlated with short-term perception of HRQoL.

摘要

## 研究目的
本研究旨在探讨1型糖尿病（Type 1 Diabetes Mellitus, T1D）患者的短期血糖控制各项参数与健康相关生活质量（Health-Related Quality of Life, HRQoL）感知水平的相关性。

## 研究对象与方法
本研究共纳入50名年龄介于18至50岁的1型糖尿病患者，所有受试者完成30天自我血糖监测（Self-Monitoring of Blood Glucose, SMBG）后，分别接受糖尿病问题量表（Problem Areas in Diabetes, PAID）与糖尿病生活质量量表（Diabetes Quality of Life, DQOL）测评。血糖控制情况通过以下指标评估：糖化血红蛋白（Glycated Hemoglobin, HbA1c）、基于过往1个月自我血糖监测数据（采用Accu-Check 360o设备）得出的平均血糖水平（Mean Glucose Levels, MGL）、低血糖发作次数（血糖＜70mg/dL及＜50mg/dL）以及血糖变异性（Glycemic Variability, GV）。

## 研究结果
糖尿病问题量表得分与平均血糖水平（r=0.52; p＜0.001）及糖化血红蛋白（r=0.36; p=0.0097）呈显著正相关，但与血糖变异性（r=0.17; p=0.23）及低血糖发作次数无显著相关性（血糖＜70mg/dL时r=0.15, p=0.17；血糖＜50mg/dL时r=0.02, p=0.85）。经多元线性回归分析后，仅平均血糖水平与糖尿病问题量表得分保持独立相关关系。
糖尿病生活质量量表得分与平均血糖水平呈正相关（r=0.45; p=0.001），但与糖化血红蛋白（r=0.23; p=0.09）、血糖变异性（r=0.20; p=0.16）及低血糖发作次数（r=0.06; p=0.68）无显著相关性。

## 研究结论
在1型糖尿病患者中，平均血糖水平是与短期健康相关生活质量感知相关性最强的血糖控制参数，而非糖化血红蛋白或低血糖发作次数。