Y chromosome mis segregation in the DLD 1 cell line

Study of the well-established DLD-1 colorectal cancer cell line, engineered with an inactivatable Y centromere that leads to mis-segregation. The goal is to gain insights into the mechanism of chromothripsis due to chromosome mis-segration.EGA study EGAS00001002551

本研究针对已成熟构建的DLD-1结直肠癌细胞系展开，该细胞系经工程改造后携带可失活的Y染色体着丝粒（centromere），该改造会引发染色体分离错误（mis-segregation）。本研究旨在深入解析由染色体分离错误所导致的染色体碎裂（chromothripsis）的发生机制。本研究为欧洲基因组表型档案（EGA）收录的EGAS00001002551号研究项目。