<b>Effect of Locally Applied Simvastatin on Dental Implant Stability: A Randomized Controlled Double-Blind Clinical Trial</b>

Bone microenvironment is known to be regenerative when simvastatin is present. Beyond its basic pharmacological function, simvastatin is a 3-hydroxy-3-methylglutaryl-coenzyme increase the production of bone morphogenetic protein-2, differentiation of osteoblasts and matrix mineralization(1-3).it enhances angiogenesis through upregulation of vascular endothelial growth factors that improve the vascular supply, Moreover, simvastatin inhibits the proinflammatory cytokines and suppressing RANKL-mediated osteoclast activity which limits early bone resorption and gives a more balance between bone formation and bone remodeling. Assessing the effect of 1.2% simvastatin on early implant stability using resonance frequency analysis.已知当辛伐他汀（simvastatin）存在时，骨微环境具备再生能力。除其基础药理功能外，辛伐他汀可通过3-羟基-3-甲基戊二酰辅酶A（3-hydroxy-3-methylglutaryl-coenzyme）通路，促进骨形态发生蛋白2（bone morphogenetic protein-2）的生成、成骨细胞分化及基质矿化(1-3)；同时可通过上调血管内皮生长因子的表达增强血管生成，改善局部血管供应。此外，辛伐他汀能够抑制促炎细胞因子，并阻断核因子κB受体活化因子配体（RANKL）介导的破骨细胞活性，从而限制早期骨吸收，实现骨形成与骨重塑之间的动态平衡。本数据集采用共振频率分析（resonance frequency analysis），评估1.2%浓度辛伐他汀对种植体早期稳定性的影响。