Crystal structure of Triazolone derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)

Crystal structure of Triazolone derivative bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394) Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-[4-(benzyloxy)phenyl]-5-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, DIMETHYL SULFOXIDE, ... Authors: Tsuji, E. Deposit date: 2010-01-14 Release date: 2011-01-19 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2 Å) Cite: Ab initio fragment molecular orbital study of ligand binding to leukocyte-specific protein tyrosine (LCK) kinase To be Published

与人淋巴细胞特异性蛋白酪氨酸激酶（LCK）的激酶结构域结合的三唑酮衍生物晶体结构，该结构域在TYR394位点发生自身磷酸化修饰。描述项：(4S)-2-甲基-2,4-戊二醇、4-[4-(苄氧基)苯基]-5-{[2-(4-氯苯基)-2-氧代乙基]硫烷基}-2,4-二氢-3H-1,2,4-三唑-3-酮、二甲基亚砜等。作者：Tsuji, E.，提交日期：2010-01-14，发布日期：2011-01-19，最后修改日期：2024-10-23。实验方法：X射线衍射（分辨率2埃）。引用文献：《配体与白细胞特异性蛋白酪氨酸激酶（LCK）结合的从头算片段分子轨道研究》，待发表。