Additional file 2 of Reduced interleukin-18 secretion by human monocytic cells in response to infections with hyper-virulent Streptococcus pyogenes

Additional file 2: Table S2. CovR/S phenotype of GAS isolates recovered from the INFECT cohort. Type of infection (poly-/monomicrobial), involvement of septic shock, CovR/CovS mutations as identified by bioinformatics, and CovR/S functionality. Data was published in [51] and re-analyzed based on CovR/S functionality. CovR/S functionality was assessed by literature review (Table S2) and protein structure prediction (Fig. S10). Yellow color indicates dysfunctional CovR/S system. Table S5. Statistical analyses of the abundance patterns of proteins of (un)infected moDCs 6 h and 24 h post indicated infections. Color code: blue: log2 fold change below 0; red: log2 fold change above 0.

附加文件2：表S2。从INFECT队列中分离的A群链球菌（Group A Streptococcus, GAS）菌株的CovR/S表型，涵盖感染类型（多微生物/单微生物感染）、是否合并脓毒性休克、经生物信息学鉴定得到的CovR/CovS突变情况，以及CovR/S系统功能状态。相关数据已在文献[51]中发表，本次研究基于CovR/S系统功能状态对其进行了重新分析。CovR/S系统功能状态通过文献调研（表S2）与蛋白质结构预测（图S10）进行评估。图表中黄色代表CovR/S系统功能失调。表S5。针对经指定感染6小时与24小时的（未）感染单核细胞源性树突状细胞（monocyte-derived dendritic cells, moDCs）的蛋白质丰度模式开展的统计学分析。颜色编码规则：蓝色代表log₂倍变化小于0；红色代表log₂倍变化大于0。