FLI1 and GATA1 govern TLN1 transcription: new insights into FLI1-related platelet disorders - Bioinformatics resources and Docker environments

This repository provides Docker containers designed to reproduce the analyses presented in Gabinaud et al. (2025), along with selected intermediate files. Detailed instructions for reproducing the analysis are available on github (https://github.com/poggiteam/FLI1_2021) and raw data and other intermediate files are available in GEO/SRA (GSE273210 / SRP522475) for the sc-RNAseq. This Zenodo hosts the following resources : Docker and Singularity images used for the analysis (cellranger5.img, citeseq-count1.4.3.img, souporcell_latest.sif and Seurat4.tar) Human reference transcriptome (refdata-gex-GRCh38-2020-A.tar.gz) Files generated by .Rmd scripts (FLI_J5_regress_no_analysis.rds, FLI_J11_regress_no_analysis.rds, 17_11_22_FLI1_manip2_ctrl_filtered_regress_no_analysis.rds, 17_11_22_FLI1_manip2_pat_filtered_regress_no_analysis.rds, 18_11_22_FLI1_manip2_combined_regress_no_analysis.rds)本仓库提供了可复现Gabinaud等人（2025）发表的分析结果的Docker容器，以及精选的中间文件。复现该分析的详细操作指南可于GitHub平台（https://github.com/poggiteam/FLI1_2021）获取；单细胞RNA测序（single-cell RNA sequencing, sc-RNAseq）的原始数据与其他中间文件，可在GEO/SRA数据库（GSE273210 / SRP522475）中下载。 本Zenodo平台托管以下资源： - 用于本次分析的Docker与Singularity镜像（含cellranger5.img、citeseq-count1.4.3.img、souporcell_latest.sif及Seurat4.tar） - 人类参考转录组文件（refdata-gex-GRCh38-2020-A.tar.gz） - 由.Rmd脚本生成的分析文件（FLI_J5_regress_no_analysis.rds、FLI_J11_regress_no_analysis.rds、17_11_22_FLI1_manip2_ctrl_filtered_regress_no_analysis.rds、17_11_22_FLI1_manip2_pat_filtered_regress_no_analysis.rds、18_11_22_FLI1_manip2_combined_regress_no_analysis.rds）