Mouse methylome and transcriptome of three brain tissues in aging

In this study, we present multi-omics profiles with the transcriptome and methylome of three brain regional tissues according to aging. For WGBS, 6 billion paired reads per sample were generated from three brain regional samples, which consisted of the hippocampus, substantia nigra, and striatum at 8 weeks and 24 months. Furthermore, 700 million paired high-quality reads were generated from the same regional and aged brain tissues using RNA-seq.

本研究发布了针对衰老进程的三类脑区组织的多组学图谱，包含转录组与甲基化组数据。针对全基因组亚硫酸氢盐测序（WGBS），本研究从8周龄与24月龄的三类脑区样本（海马体、黑质、纹状体）中，为每个样本生成了60亿条双端读数。此外，本研究通过RNA测序（RNA-seq）技术，对上述同一脑区的不同衰老阶段脑组织进行测序，共生成7亿条高质量双端读数。