Significant psychophysiological interaction effects.

Transient alterations were defined as a cold-induced increase in functional coupling between seed region and clusters present when contrasting cold stimulation to the affected limb versus in the CRPS state versus a) the unaffected limb in the CRPS state; b) the affected limb in the recovered state; and c) the unaffected limb in the recovered state. Persistent alterations were defined as regions with a cold-induced increase in functional coupling between seed region present in both the CRPS state (versus unaffected limb) and in the symptomatically recovered state (affected vs unaffected limb). Cluster size for entire clusters, with sub-peak coordinates. Regions indicate nearest (