The use of sodium ascorbate to recover the bond strength to sodium hypochlorite-treated dentin: a scoping review

This scoping review aimed to investigate whether sodium ascorbate can recover the bond strength of resin composite restorations to sodium hypochlorite (NaOCl)-treated dentin. The protocol of this study, available online (https://osf.io/psj3v/), followed the Joana Briggs Institute guidelines. The PRISMA Extension for Scoping Reviews was used to reporting. <i>In vitro</i> studies evaluating the effect of sodium ascorbate on NaOCl-treated dentin and resin composite restorations, regardless of the adhesive material used, were included without time restriction. The search and study screening were conducted in Embase, PubMed, Scopus, and Web of Science by two independent researchers. A descriptive analysis was performed and the PRILE 2021 guidelines were used to assess the risk bias of the included studies. The initial search yielded 941 studies, of which only 7 studies were included. The findings revealed that extracted third molars were the most used samples, and there was a significant variation in the NaOCl concentration employed. In general, sodium ascorbate effectively restored the compromised bond strength in dentin treated with different NaOCl concentrations. Furthermore, regarding the failure mode, the most prevalent observed was mixed failure. This scoping review showed that sodium ascorbate appears to effectively recover the bond strength of resin composite restorations to dentin treated with NaOCl. However, it is important to note the limited number of studies and the heterogeneity observed.

本范围综述旨在探究抗坏血酸钠能否恢复经次氯酸钠（NaOCl）处理的牙本质与树脂复合修复体之间的粘结强度。本研究的方案可在线获取（https://osf.io/psj3v/），遵循了乔安娜·布里格斯研究所（Joana Briggs Institute）的指南，并采用PRISMA范围综述扩展声明（PRISMA Extension for Scoping Reviews）进行报告撰写。
无论所使用的粘接材料类型如何，所有评估抗坏血酸钠对经NaOCl处理的牙本质及树脂复合修复体影响的体外研究（In vitro）均被纳入，且无时间限制。检索与文献筛选工作由两名独立研究者在Embase、PubMed、Scopus及Web of Science数据库中完成。本研究采用描述性分析方法，并依据PRILE 2021指南（PRILE 2021）对纳入研究的偏倚风险进行评估。
初步检索共获取941篇文献，最终仅纳入7篇。研究结果显示，最常用的实验样本为拔除的第三磨牙，且所使用的NaOCl浓度存在显著差异。总体而言，抗坏血酸钠可有效恢复经不同浓度NaOCl处理的牙本质所受损的粘结强度。此外，就修复体的破坏模式而言，最为常见的为混合破坏。
本范围综述表明，抗坏血酸钠似乎可有效恢复经NaOCl处理的牙本质与树脂复合修复体之间的粘结强度。但需注意的是，当前相关研究数量有限，且纳入研究间存在明显的异质性。