Circulating MicroRNAs From Serum Small Extracellular Vesicles as Potential diagnostic Biomarkers in Pediatric Epilepsy and Drug-Resistant Epilepsy. Circulating MicroRNAs From Serum Small Extracellular Vesicles as Potential diagnostic Biomarkers in Pediatric Epilepsy and Drug-Resistant Epilepsy

Pediatric epilepsy is a neurological condition that causes repeated and unprovoked seizures and is more common in 1–5-year-old children. Drug resistance has been indicated as a key challenge in improving the clinical outcomes of patients with pediatric epilepsy. In the present study, we aimed to identify serum small extracellular vesicles (sEVs) derived microRNAs (miRNAs) from the serum samples of children for predicting the prognosis in patients with epilepsy and drug-resistant epilepsy Overall design: Expression of circulating miRNAs from serum sEVs between epileptic children and healthy children was assessed in this multiphase case-control study.

小儿癫痫（Pediatric epilepsy）是一种以反复无诱因发作为特征的神经系统疾病，好发于1~5岁儿童。耐药性是制约小儿癫痫患者临床结局改善的核心挑战。本研究旨在从儿童血清样本中筛选源自血清小细胞外囊泡（small extracellular vesicles，简称sEVs）的微小RNA（miRNAs），以预测癫痫及耐药性癫痫患者的预后。研究整体设计：本项多阶段病例对照研究评估了癫痫患儿与健康儿童血清sEVs来源的循环miRNAs表达水平。