Additional Supplement Data of the manuscript "Multi-Ancestry Epigenome-Wide Association Study of Asthma Exacerbations""

For this manuscript we conducted a meta-analysis from epigenome-wide association study of asthma exacerbations in 599 Latino and 394 African Americans as discovery ("2_EWAS_MetaResults_Multiancestry_GALA_SAGE__bacon_exacerbations_mval_lineal_age_sex_pcs_rcs_filtered.txt"). In addition, we also performed a multi-ancestry meta-analysis including GEMAS study, which included 312 Canary Islanders and 94 Basques ("2_EWAS_MetaResults_Multiancestry_GALA_SAGE_CAN_PV_bacon_exacerbations_mval_lineal_age_sex_pcs_rcs_filtered.txt"). Summary statistics output is organized in the following columns: RSID: Probe ID STUDY: number of studies or subsets were is present the probe BETA_meta: coefficient estimate SEBETA_meta: standard error PVALUE_meta: raw p-value PVALUE_Q: p-value of Cochran’s Q Model: FE (fixed effect) or RE2 (random effect) PVALUE_meta_adj: adjusted p-value by false discovery rate本研究基于纳入599名拉丁裔与394名非裔美国人的哮喘急性加重表观基因组全关联研究（epigenome-wide association study，EWAS）开展荟萃分析，该分析作为发现队列，所用结果文件为"2_EWAS_MetaResults_Multiancestry_GALA_SAGE__bacon_exacerbations_mval_lineal_age_sex_pcs_rcs_filtered.txt"。此外，本研究还纳入GEMAS研究开展多族裔荟萃分析，该研究包含312名加那利群岛居民与94名巴斯克受试者，所用结果文件为"2_EWAS_MetaResults_Multiancestry_GALA_SAGE_CAN_PV_bacon_exacerbations_mval_lineal_age_sex_pcs_rcs_filtered.txt"。 本次输出的汇总统计数据包含以下列项： RSID：探针ID STUDY：该探针所涉及的研究或子集数量 BETA_meta：荟萃分析系数估计值 SEBETA_meta：标准误 PVALUE_meta：原始P值 PVALUE_Q：科克伦Q检验P值 Model：固定效应（FE）或随机效应（RE2） PVALUE_meta_adj：经错误发现率校正的P值