DataSheet_1_Publication trends of research on sepsis and programmed cell death during 2002–2022: A 20-year bibliometric analysis.csv

BackgroundSepsis is considered an intractable dysfunction that results from the disordered host immune response to uncontrolled infection. Even though the precise mechanism of sepsis remains unclear, scientific advances have highlighted the key role of various programmed cell death processes in the pathophysiology of sepsis. The current study aims to explore the worldwide research trend on programmed cell death in the setting of sepsis and assesses the achievements of publications from various countries, institutions, journals, and authors globally.
Material and methodsAssociated publications during 2002–2022 with the topical subject of sepsis and programmed cell death were extracted from the Web of Science. VOSviewer was utilized to evaluate and map the published trend in the relevant fields.
ResultsAll 2,037 relevant manuscripts with a total citation of 71,575 times were screened out by the end of 1 January 2022. China accounted for the largest number of publications (45.07%) and was accompanied by corporate citations (11,037) and H-index (48), which ranked second globally. The United States has been ranked first place with the highest citations (30,775) and H-index (88), despite a low publication number (29.95%), which was subsequent to China. The journal Shock accounted for the largest number of publications in this area. R. S. Hotchkiss, affiliated with Washington University, was considered to have published the most papers in the relevant fields (57) and achieved the highest citation frequencies (9,523). The primary keywords on the topic of programmed cell death in sepsis remarkably focused on “inflammation” “immunosuppression”, and “oxidative stress”, which were recognized as the core mechanisms of sepsis, eventually attributing to programmed cell death. The involved research on programmed cell death induced by immune dysregulation of sepsis was undoubtedly the hotspot in the pertinent areas.
ConclusionsThe United States has been academically outstanding in sepsis-related research. There appears to be an incompatible performance between publications and quantity with China. Frontier advances may be consulted in the journal Shock. The leading-edge research on the scope of programmed cell death in sepsis should preferably focus on immune dissonance-related studies in the future.

背景 脓毒症（Sepsis）被认为是一种难治性功能障碍，由宿主对失控感染的紊乱免疫应答所引发。尽管脓毒症的确切发病机制仍未明确，但科学研究进展已凸显出各类程序性细胞死亡（programmed cell death）过程在脓毒症病理生理学中的关键作用。本研究旨在探究脓毒症背景下程序性细胞死亡领域的全球研究趋势，并评估全球范围内不同国家、机构、期刊及作者的学术成果。
材料与方法 从Web of Science数据库中提取2002年至2022年间与脓毒症及程序性细胞死亡主题相关的文献，使用VOSviewer对相关领域的发表趋势进行评估与可视化制图。
结果 截至2022年1月1日，共筛选出2037篇相关文献，总引用量达71575次。中国的发文量占比最高（45.07%），机构引用量达11037次，H指数为48，位列全球第二。美国虽发文量仅次于中国（29.95%），但总引用量（30775次）与H指数（88）均位居全球首位。《Shock》期刊是该领域发文量最高的期刊。华盛顿大学的R·S·霍奇基斯（R. S. Hotchkiss）是该领域发文量最多的作者（57篇），总引用频次达9523次，位列第一。脓毒症程序性细胞死亡主题的核心关键词集中于“炎症”“免疫抑制”与“氧化应激”，上述因素被认为是脓毒症的核心发病机制，并最终介导程序性细胞死亡的发生。针对脓毒症免疫失调诱导的程序性细胞死亡的相关研究，无疑是该领域的研究热点。
结论 美国在脓毒症相关研究领域的学术表现尤为突出。中国的发文量与学术影响力表现存在失衡情况。可通过《Shock》期刊获取该领域的前沿研究进展。未来脓毒症程序性细胞死亡领域的前沿研究，可优先聚焦于免疫失调相关方向。