Optical coherence tomography detection of changes in inner retinal and choroidal thicknesses in patients with early retinitis pigmentosa

ABSTRACT Purpose: To evaluate the inner retinal and choroidal thicknesses in patients with early retinitis pigmentosa. Methods: We analyzed spectral-domain optical coherence tomography images of 35 retinitis pigmentosa patients and 40 healthy individuals. We measured macular and ganglion cell complex thicknesses. We took choroidal thickness measurements in the subfoveal region and 500, 1,000, and 1,500 mm from the foveal center. Results: Patients with retinitis pigmentosa had significantly thinner macular thicknesses and choroidal thicknesses in all measurements, and their individual ganglion cell complex thickness measurements were lower than those in healthy individuals. The mean ganglion cell complex thickness was significantly lower in patients with retinitis pigmentosa than that in controls. The mean macular thickness was significantly correlated with the mean choroidal and mean ganglion cell complex thicknesses. (We found no correlation between the mean choroidal thickness and the mean ganglion cell complex thickness). Conclusions: The choroid was mildly affected in our patients with early retinitis pigmentosa. The tendency toward significance in the inner retina was possibly caused by a good visual acuity.

摘要
研究目的：评估早期色素性视网膜炎（retinitis pigmentosa）患者的视网膜内层与脉络膜厚度。
研究方法：本研究对35例色素性视网膜炎患者及40名健康个体的光谱域光学相干断层成像（spectral-domain optical coherence tomography）图像进行分析，测量了黄斑区与神经节细胞复合体（ganglion cell complex）厚度，并在黄斑中心凹下区域以及距中心凹中心500、1000、1500毫米处进行脉络膜厚度测量。
研究结果：色素性视网膜炎患者的所有测量指标中，黄斑厚度与脉络膜厚度均显著变薄，且其神经节细胞复合体各项测量值均低于健康对照组；患者的平均神经节细胞复合体厚度显著低于健康对照组。平均黄斑厚度与平均脉络膜厚度、平均神经节细胞复合体厚度均呈显著相关性，但平均脉络膜厚度与平均神经节细胞复合体厚度之间未发现相关性。
研究结论：本研究纳入的早期色素性视网膜炎患者脉络膜仅受轻度累及；视网膜内层出现的具有统计学显著性的变化趋势，可能与患者较好的视力有关。