Supplementary Material for: Delivery Room Handling of the Newborn. Filling the Gaps

Background
Newborn resuscitation algorithms have since the turn of the century been more evidence-based. In this review, we discuss the development of American Heart Association (AHA) and the International Liaison Committee on Resuscitation (ILCOR)’s algorithm for newborn resuscitation from 1992-2024. We have also aimed to identify the remaining gaps in non-evidenced practice.
Summary
Of the 22 procedures reviewed in the 2020 ILCOR recommendations, the evidence was either low, very low, or non-existing. The strength of recommendation is weak or non-existing for most topics discussed. Several knowledge gaps are also summarized. The special challenge for low and middle income countries (LMIC) is discussed specifically.
Key messages
Newborn resuscitation is still not evidence-based although great progress has been achieved the recent years. We have identified several knowledge gaps which should be prioritized in future research. The challenge of obtaining evidence-based knowledge from LMIC should be focused on in future research.

研究背景
自本世纪初以来，新生儿复苏算法愈发注重循证依据。本综述将梳理美国心脏协会（American Heart Association, AHA）与国际复苏联盟（International Liaison Committee on Resuscitation, ILCOR）1992年至2024年间发布的新生儿复苏算法的演进历程，同时旨在明确当前仍缺乏循证依据的临床实践尚存的空白领域。

研究综述概要
在2020年ILCOR指南所评估的22项操作中，相关证据等级均为低质量、极低质量或完全缺乏证据。本次综述涉及的多数议题，其推荐强度均为弱推荐或无明确推荐。此外本综述还梳理了多项认知空白，且专门探讨了中低收入国家（Low and Middle Income Countries, LMIC）所面临的特殊挑战。

核心观点
尽管近年已取得长足进展，但新生儿复苏实践仍未完全实现循证化。本研究已明确多项亟需在未来研究中优先开展的认知空白，未来研究应重点关注从LMIC获取循证依据所面临的挑战。